张力素
破骨细胞
小RNA
成骨细胞
肌发生
生物
调节器
旁分泌信号
串扰
骨重建
癌症研究
PTEN公司
细胞生物学
信号转导
基因
心肌细胞
PI3K/AKT/mTOR通路
内分泌学
遗传学
受体
光学
物理
体外
作者
Youqiang Sun,Vincent Kuek,Kun Wang,Jennifer Tickner,Yu Yuan,Leilei Chen,Zhilin Zeng,Min Shao,Wei He,Jiake Xu
摘要
MiR-214 belongs to a family of microRNA (small, highly conserved noncoding RNA molecules) precursors that play a pivotal role in biological functions, such as cellular function, tissue development, tissue homeostasis, and pathogenesis of diseases. Recently, miR-214 emerged as a critical regulator of musculoskeletal metabolism. Specifically, miR-214 can mediate skeletal muscle myogenesis and vascular smooth muscle cell proliferation, migration, and differentiation. MiR-214 also modulates osteoblast function by targeting specific molecular pathways and the expression of various osteoblast-related genes; promotes osteoclast activity by targeting phosphatase and tensin homolog (Pten); and mediates osteoclast-osteoblast intercellular crosstalk via an exosomal miRNA paracrine mechanism. Importantly, dysregulation in miR-214 expression is associated with pathological bone conditions such as osteoporosis, osteosarcoma, multiple myeloma, and osteolytic bone metastasis of breast cancer. This review discusses the cellular targets of miR-214 in bone, the molecular mechanisms governing the activities of miR-214 in the musculoskeletal system, and the putative role of miR-214 in skeletal diseases. Understanding the biology of miR-214 could potentially lead to the development of miR-214 as a possible biomarker and a therapeutic target for musculoskeletal diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI