化学
转氨作用
产量(工程)
组合化学
立体化学
对映选择合成
钙通道
敌手
吡啶
催化作用
钙
有机化学
受体
材料科学
冶金
酶
生物化学
作者
Yong‐Li Zhong,Jeffrey C. Moore,Michael Shevlin,C. Scott Shultz,Birgit Kosjek,Yonggang Chen,Jacob M. Janey,Lushi Tan
标识
DOI:10.1021/acs.joc.1c01795
摘要
Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building block. The key step to set the stereochemistry relied on either chiral rhodium catalyst-mediated asymmetric hydrogenation of an enamide or transamination of an arylketone that provided the corresponding product in high enantioselectivity and high yield.
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