鼻息肉
免疫学
CD38
医学
人口
免疫系统
流式细胞术
鼻窦炎
病理
生物
干细胞
川地34
遗传学
环境卫生
作者
Min‐Seok Rha,Young Hoon Yoon,June-Young Koh,Jae Hyung Jung,Ha Seok Lee,Soo Kyung Park,Su–Hyung Park,Yong Min Kim,Ki-Sang Rha,Eui–Cheol Shin
标识
DOI:10.1016/j.jaci.2021.07.037
摘要
Diverse immune cells contribute to the pathogenesis of chronic rhinosinusitis (CRS), an inflammatory disease of the nasal cavity and paranasal sinuses. However, whether mucosal-associated invariant T (MAIT) cells are present in human sinonasal tissues remains unclear. Furthermore, the characteristics of sinonasal MAIT cells have not been studied in patients with CRS.We investigated the phenotype, function, and clinical implications of MAIT cells in patients with CRS.Peripheral blood and sinonasal tissue were obtained from patients with CRS with (CRSwNP) or without nasal polyps (CRSsNP) and healthy controls. MAIT cells were analyzed by flow cytometry.We found that MAIT cells are present in human sinonasal tissues from healthy controls and patients with CRS. The sinonasal MAIT cell population, but not peripheral blood MAIT cells, from patients with CRSsNP, noneosinophilic CRSwNP (NE-NP), or eosinophilic CRSwNP (E-NP) had a significantly higher frequency of activated cells marked by CD38 expression. In functional analysis, the sinonasal MAIT cell population from NE-NP and E-NP had a significantly higher frequency of IL-17A+ cells but lower frequency of IFN-γ+ or TNF+ cells than control sinonasal tissues. Furthermore, CD38 expression and IL-17A production by sinonasal MAIT cells significantly correlated with disease extent evaluated by the Lund-Mackay computed tomography score in patients with E-NP.Sinonasal MAIT cells exhibit an activated phenotype and produce higher levels of IL-17A in patients with CRSwNP. These alterations are associated with the extent of disease in patients with E-NP.
科研通智能强力驱动
Strongly Powered by AbleSci AI