立体选择性
化学
烯醇
催化作用
产量(工程)
共轭体系
组合化学
立体化学
有机化学
聚合物
冶金
材料科学
作者
Chuan‐Jin Hou,Alexander Schuppe,James Levi Knippel,Anton Z. Ni,Stephen L. Buchwald
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-11-02
卷期号:23 (22): 8816-8821
被引量:9
标识
DOI:10.1021/acs.orglett.1c03324
摘要
Conjugated dienes are versatile building blocks and prevalent substructures in synthetic chemistry. Herein, we report a method for the stereoselective hydroalkenylation of alkynes, utilizing readily available enol triflates. We leveraged an in situ-generated and geometrically pure vinyl-Cu(I) species to form the Z,Z- or Z,E-1,3-dienes in excellent stereoselectivity and yield. This approach allowed for the synthesis of highly substituted Z-dienes, including pentasubstituted 1,3-dienes, which are difficult to prepare by existing approaches.
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