等温滴定量热法
化学
环糊精
埃及伊蚊
超分子化学
水溶液
Zeta电位
核化学
有机化学
物理化学
幼虫
分子
材料科学
纳米技术
纳米颗粒
植物
生物
作者
Vanessa C. E. Bittencourt,Ana Moreira,Alexandre Rodrigues Ferreira,Erúzia A. E Ferreira,Antônio Frederico de Freitas Gomides,Cibele Isaac Saad Rodrigues,Gustavo Ferreira Martins,Jeferson G. Da Silva,Keyller Bastos Borges,Ângelo M. L. Denadai
标识
DOI:10.21577/0103-5053.20210093
摘要
This study searched for a new pre-formulation based on the natural compound from the class of the avermectins, named abamectin (ABA), in order to improve its action against Aedes aegypti larvae by complexation with β-cyclodextrin (βCD). Concerning the low aqueous solubility of ABA, even in the presence of βCD, it was also invoked the strategy of working with hydrophobic nanoprecipitates (HNPs). For these purposes, molecular and supramolecular characterizations of 1:1 ABA/βCD complex and evaluation of its toxicity against A. aegypti larvae were performed. In the physical-chemistry characterizations, changes in the infrared spectra and thermal profiles in relation to precursors confirmed the occurrence of interactions between ABA and βCD in solid state. Nuclear magnetic resonance (NMR) data suggest the inclusion of ABA in βCD via benzofuran ring. Isothermal titration calorimetry (ITC) experiments allowed to verify the formation of complex with a 1:1 stoichiometry, which was entropy driven. The dynamic light scattering and zeta potential data from inclusion compounds demonstrated changes in the size of the ABA/βCD HNP if compared with the ABA HNP. Finally, the results for biological assays demonstrate that the strategy to prepare the inclusion compound led to an increase in the larvicidal activity in relation to free ABA.
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