BMPR2型
发病机制
转化生长因子
医学
骨形态发生蛋白
ACVRL1型
骨形态发生蛋白受体
肺动脉高压
信号转导
细胞生物学
内科学
癌症研究
内皮糖蛋白
生物
基因
遗传学
干细胞
川地34
作者
Nahid Sharmin,Chinyere Chioma Nganwuchu,Talat Nasim
标识
DOI:10.1016/j.tips.2021.04.002
摘要
Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and clinical symptoms. This forum highlights the association of the TGF-β pathway with pathogenesis and therapeutic approaches. Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and clinical symptoms. This forum highlights the association of the TGF-β pathway with pathogenesis and therapeutic approaches.
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