血小板源性生长因子受体
血管生成
体内
背景(考古学)
伤口愈合
体外
医学
肌腱
药理学
血小板衍生生长因子
细胞生物学
生长因子
化学
生物医学工程
免疫学
癌症研究
生物
外科
内科学
生物化学
生物技术
受体
古生物学
作者
Olivera Evrova,Johanna Buschmann
出处
期刊:European Cells & Materials
日期:2017-07-17
卷期号:34: 15-39
被引量:55
摘要
To promote and support tendon healing, one viable strategy is the use or administration of growth factors at the wound/rupture site. Platelet derived growth factor-BB (PDGF-BB), together with other growth factors, is secreted by platelets after injury. PDGF-BB promotes mitogenesis and angiogenesis, which could accelerate tendon healing. Therefore, in vitro studies with PDGF-BB have been performed to determine its effect on tenocytes and tenoblasts. Moreover, accurate and sophisticated drug delivery devices, aiming for a sustained release of PDGF-BB, have been developed, either by using heparin-binding and fibrin-based matrices or different electrospinning techniques. In this review, the structure and composition, as well as the healing process of tendons, are described. Part A deals with in vitro studies. They focus on the multiple effects evoked by PDGF-BB on the cellular level. Moreover, they address strategies for the sustained delivery of PDGF-BB. Part B focuses on animal models used to test different delivery strategies for PDGF-BB, in the context of tendon reconstruction. These studies showed that dosage and timing of PDGF-BB application are the most important factors for deciding which delivery device should be applied for a specific tendon laceration.
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