FOXP3型
生物
表观遗传学
转录因子
功能(生物学)
Treg细胞
遗传学
免疫学
计算生物学
细胞生物学
T细胞
基因
免疫系统
白细胞介素2受体
作者
Yohko Kitagawa,Shimon Sakaguchi
标识
DOI:10.1016/j.coi.2017.10.002
摘要
Treg cells expressing the transcription factor Foxp3 are essential for immunological tolerance and homeostasis. Recent genome-wide studies have revealed that Foxp3+ natural Treg cells possess a number of unique transcriptional and epigenetic features, which appear to be acquired along the course of Treg cell development and maintained throughout their lifespan. These studies also provide novel insights into how genomic variations contribute to genetic susceptibility to human autoimmune diseases by affecting Treg cell development and function.
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