信号转导
功能(生物学)
受体
激素
生物
细胞生物学
孕酮受体
内分泌学
内科学
医学
生物化学
遗传学
雌激素受体
癌症
乳腺癌
作者
Deepika Garg,Sinnie Sin Man Ng,K. Maravet Baig,Paul H. Driggers,James H. Segars
标识
DOI:10.1016/j.tem.2017.05.006
摘要
Progesterone is essential for pregnancy maintenance and menstrual cycle regulation. Hormone action has been primarily ascribed to the well-characterized classical signaling pathway involving ligand binding, activation of nuclear progesterone receptors (PRs), and subsequent activation of genes containing progesterone response elements (PREs). Recent studies have revealed progesterone actions via non-classical signaling pathways, often mediated by non-genomic signaling. Progesterone signaling, in conjunction with growth factor signaling, impacts on the function of growth factors and regulates important physiological actions such as cell growth and remodeling, as well as apoptosis. This review focuses on non-classical progesterone signaling pathways, both including and excluding PR, and highlights how research in this area will provide a better understanding of progesterone actions and may inform novel therapeutic strategies.
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