黄斑变性
医学
眼科
入射(几何)
变性(医学)
风险因素
光动力疗法
外科
内科学
化学
有机化学
物理
光学
作者
Akira Machida,Akio Oishi,Eiko Tsuiki,Yuki Maekawa,Junko Kurihara,Yuki Hirata,Eriko Machida,Takashi Kitaoka
出处
期刊:Retina-the Journal of Retinal and Vitreous Diseases
[Ovid Technologies (Wolters Kluwer)]
日期:2023-06-01
卷期号:43 (6): 888-896
标识
DOI:10.1097/iae.0000000000003740
摘要
Purpose: To investigate the incidence, risk factors, and outcomes of patients with age-related macular degeneration who experienced acute vision loss despite periodic injections of anti–vascular endothelial growth factor treatment for 4 years. Methods: This retrospective cohort study included patients who were diagnosed with treatment-naive neovascular age-related macular degeneration and completed a 4-year follow-up. The incidence and risk factors for the occurrence of three or more lines of visual loss at every checkup were investigated. Results: The analysis included 76 eyes of 76 patients. Acute vision loss occurred in 30 eyes (39.5%) over 4 years. Lower baseline best-corrected visual acuity and disrupted ellipsoid zone were independent predictors of vision loss occurrence. Although the causes and timing of visual acuity loss varied, retinal pigment epithelium tears were observed only in the first year. Most patients (86.7%) who experienced vision loss recovered their vision to pre-loss levels at least once; however, the final best-corrected visual acuity was worse than that in the group that did not experience acute vision loss. Conclusion: Approximately half of the patients with age-related macular degeneration experienced acute vision loss during a 4-year follow-up, despite continuous anti–vascular endothelial growth factor treatment. Most patients recovered from vision losses temporarily; however, they experienced worse visual outcomes subsequently.
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