Purpose This study aims to explore the interplay between supply chain collaboration and disruption and their joint impact on supply chain resilience. It also aims to identify the configurational conditions under which supply chain resilience is achieved, providing a holistic framework for enhancing supply chain management practices amidst disruptions. Design/methodology/approach This study uses a fuzzy-set qualitative comparative analysis (fsQCA) to investigate the complex causal mechanisms linking supply chain collaboration and disruption with supply chain resilience. The research integrates three dimensions of collaboration with three dimensions of disruption, offering a comprehensive understanding of supply chain resilience factors. Findings This study reveals that supply chain resilience is not solely dependent on individual elements but is shaped by unique configurations of collaboration and disruption factors. Information sharing emerges as a core factor in high resilience, while the absence of supply and facility disruptions significantly influences resilience outcomes. The research highlights the importance of multiple paths leading to supply chain resilience and the asymmetrical impact of collaboration and disruption. Research limitations/implications The study acknowledges limitations due to data sourced exclusively from China and the use of static data, suggesting the need for cross-temporal and international samples to enhance broader applicability. Future research should consider dynamic temporal changes and diverse theoretical perspectives to comprehensively examine the factors influencing supply chain resilience. Practical implications The research underscores the critical role of information sharing in bolstering supply chain resilience and advises firms to prioritize it in their strategies. It also highlights the importance of mitigating supply and facility disruptions through supplier diversification and robust contingency planning, offering actionable insights for enhancing operational efficiency and risk management in supply chain management. Social implications This research has significant social implications, particularly in the context of global supply chain disruptions. By identifying key factors that enhance supply chain resilience, it can help businesses better prepare for and respond to crises, thereby reducing economic instability and social disruption. Improved resilience can lead to more stable employment, maintain the flow of essential goods and services and contribute to overall societal well-being during times of supply chain stress. Originality/value This study offers original insights by applying fsQCA to explore the multifaceted relationship between supply chain collaboration, disruption and resilience. Its value lies in revealing the complex causal configurations that lead to high or low levels of supply chain resilience, challenging traditional linear perspectives and providing a nuanced understanding that can guide both academic research and practical supply chain management strategies.