光敏剂
单线态氧
体内
化学
光动力疗法
青霉素
抗生素
体外
光化学
氧气
生物化学
生物
生物技术
有机化学
作者
Chao Zhao,Wanlu Sun,Baojin Tan,Dan Su,Yi Liu
标识
DOI:10.1016/j.snb.2023.133502
摘要
The antibiotic therapy usually leads to the bacterial resistance, and the traditional photosensitizer was in “always on” state with damage to normal tissue. Fortunately, the activatable near-infrared photosensitizer has a high depth of tissue penetration, and can be specifically released with low side effect. Therefore, we designed and synthesized a penicillin G acylase (PGA) activable photosensitizer (NFh-PGA), which could be activated to produce NFh-OH. NFh-OH can product singlet oxygen (1O2) under near-infrared light 730 nm excitation, and have an excellent antibacterial effect in vitro and in vivo. The probe accelerates the healing of bacterial infection wounds by near-infrared imaging guiding PDT. This work provides a strategy for the integrated design of diagnosis and treatment of bacterial infection.
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