化学
电合成
分子内力
亲核细胞
砜
电化学
组合化学
氧化还原
钠
基质(水族馆)
有机化学
电极
催化作用
海洋学
物理化学
地质学
作者
Xue‐Qing Mou,Liang-Chen Ren,Min Wang,Huan‐Huan Zhang,Ang Cai,Kuan-Xin Wan,Shimin Zhang,Bao‐Dong Cui,Yun Zhang,Yong‐Zheng Chen
标识
DOI:10.1021/acs.joc.3c00015
摘要
A practical and efficient electrochemical intramolecular amino- or oxysulfonylation of internal alkenes equipped with pendant nitrogen or oxygen-centered nucleophiles with sodium sulfinate was developed. Under undivided electrolytic cell conditions, a variety of sulfonylated N-heterocycles and O-heterocycles, such as tetrahydrofurans, tetrahydropyrans, oxepanes, tetrahydropyrroles, piperidines, δ-valerolactones, etc., were efficiently prepared from easily accessible unsaturated alcohols, carboxylic acids, and N-tosyl amines without the need for additional metal or exogenous oxidant. The robust electrochemical transformation features excellent redox economy, high diastereoselectivity, and broad substrate specificity, which provide a general and practical access to sulfone-containing heterocycles and would facilitate the related synthetic and biological studies based on this electrosynthesis.
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