Safety and efficacy of selective and superselective intra-arterial cerebral infusion with blood–brain barrier disruption for glioma: a systematic review and meta-analysis

The findings indicate that SIACI/SSIACI chemotherapy following BBBd is a feasible and safe approach for glioma treatment, demonstrating a favorable procedural risk profile and preliminary signs of efficacy. Further studies are warranted to validate these results and refine procedural protocols.