Early Prognostic Factors for Reduced Survival in Autoimmune Hepatitis: A Systematic Review With Meta-Analysis

Cirrhosis and insufficient treatment response are the prognostic factors with the highest impact on reduced survival in AIH. Other risk factors include advanced age, non-Caucasian ethnicity, primary sclerosing cholangitis-variant syndrome, asymptomatic presentation, higher relapse rates and elevated international normalized ratio, creatinine, alkaline phosphatase/aspartate aminotransferase ratio, and Model for End-stage Liver Disease score, whereas elevated baseline aminotransferases and albumin are protective.