In this study, the microstructure and texture evolution of pure titanium sheets under different cold rolling reduction (20%-80%) and annealing time (10–60 min) were systematically analyzed, and the mechanism of plastic deformation and static recrystallization (SRX) was revealed. The results show that: In the process of plastic deformation, 20%-40% reduction is dominated by {11-22}<11-2-3> compression twins and {10-12}<10-1-1> tensile twins, which coordinate plastic deformation and refine grains. When the reduction is 40–60%, it gradually changes to dislocation slip. At 60–80%, it is dominated by dislocation slip, and the lattice rotation forms a strong TD splitting texture. In the process of static recrystallization, the nucleation of non-basal oriented grains in the twinning zone is dominated by 20–40% reduction. With the increase of deformation, the grains form off-basal oriented grains by grain boundary migration. The generation of non-basal grains leads to the dispersion distribution of texture, and the generation of off-basal grains re-forms a strong TD splitting texture. At 80% high reduction, with the increase of annealing time, the non-basal grains with high grain boundary mobility shrink inward and disappear, and the off-basal grains grow and form a stable structure.