止血
补体系统
生物
替代补体途径
免疫学
背景(考古学)
经典补体途径
免疫系统
细胞生物学
血小板
补语(音乐)
凝结
表型
遗传学
医学
基因
互补
古生物学
内科学
精神科
作者
Marina Noris,Miriam Galbusera
摘要
Summary The complement and hemostatic systems are complex systems, and both involve enzymatic cascades, regulators, and cell components—platelets, endothelial cells, and immune cells. The two systems are ancestrally related and are defense mechanisms that limit infection by pathogens and halt bleeding at the site of vascular injury. Recent research has uncovered multiple functional interactions between complement and hemostasis. On one side, there are proteins considered as complement factors that activate hemostasis, and on the other side, there are coagulation proteins that modulate complement. In addition, complement and coagulation and their regulatory proteins strongly interact each other to modulate endothelial, platelet and leukocyte function and phenotype, creating a potentially devastating amplifying system that must be closely regulated to avoid unwanted damage and\or disseminated thrombosis. In view of its ability to amplify all complement activity through the C3b‐dependent amplification loop, the alternative pathway of complement may play a crucial role in this context. In this review, we will focus on available and emerging evidence on the role of the alternative pathway of complement in regulating hemostasis and vice‐versa, and on how dysregulation of either system can lead to severe thromboinflammatory events.
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