骨重建
医学
骨保护素
牙科
维生素D与神经学
牙周纤维
骨吸收
生物标志物
内科学
生物
激活剂(遗传学)
受体
生物化学
作者
Martina Ferrillo,Dario Calafiore,Lorenzo Lippi,Francesco Agostini,Mario Migliario,Marco Invernizzi,Amerigo Giudice,Alessandro de Sire
出处
期刊:Korean Journal of Orthodontics
[Korean Association of Orthodontists]
日期:2023-09-22
卷期号:54 (1): 26-47
摘要
: This systematic review aimed to evaluate the correlation between vitamin D levels and the rate of tooth movement, external apical root resorption, bone biomarker expression, and bone remodeling.: Three databases (PubMed, Scopus, and Web of Science) were systematically searched from inception until 14th March 2023 to identify studies investigating the correlation between orthodontic tooth movement and vitamin D in animals and humans. The quality assessment was made in accordance with the Joanna Briggs Institute Critical Appraisal Checklist.: Overall, 519 records were identified, and 19 were selected for the qualitative synthesis. Eleven studies investigated the effect of local administration (injections in the periodontal ligament, to the gingiva distal to the teeth, or submucosae palatal area) and systemic administration (oral supplementation) of vitamin D on tooth movement, external apical root movement, pro-inflammatory cytokines, and bone remodeling factors. The remaining eight studies investigated the correlation between serum vitamin D levels and salivary vitamin D levels on bone turnover markers and tooth movement.: The findings of this systematic review support that vitamin D3 local injections might increase the rate of tooth movement via the receptor activator of the nuclear factor-kB/osteoprotegerin axis. However, the non-uniform study designs and the different protocols and outcome methods make it challenging to draw reliable conclusions.
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