Secondary Alkyl Ketoximes in the Trofimov Reaction: From Minor Products to 21st Century Reagents

Abstract The review summarizes the results and prospects of studying the reactions of acetylene with secondary alkyl ketoximes containing only one C–H bond at the α-position with respect to the oxime group in superbasic medium. The selective formation of key intermediate products in the pyrrole synthesis (3 H -pyrroles and 5-hydroxypyrrolines), their reactivity, and unique cascade assemblies of unexpected compounds are discussed.