材料科学
唾液
纳米技术
薄膜
挥发性有机化合物
化学工程
化学
有机化学
生物化学
工程类
作者
Yuna Zhang,Haizi Yao,Cuili Xue,Yang Xu,Chenghan Yi,Yi‐Yang Sun,Shengsheng Cui,Nguyễn Đức Hòa,Abolghasem Jouyban,Han Jin,Daxiang Cui
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2024-01-26
标识
DOI:10.1021/acsanm.3c04835
摘要
Mortality of gastric cancer is the second in cancer-associated deaths due to the lack of specific symptoms at an early stage, and thus, early detection of gastric cancer is receiving more attention. Nowadays, volatile organic compound (VOC) indicators have been found to be helpful for screening a variety of cancers. Meanwhile, hybrid VOC indicators, namely, VOCs derived from both human breath and body fluids, provide more information about health status. Nevertheless, details of VOCs in body fluid (e.g. saliva) are still unclear and tracking of these VOCs remains a challenge. In this research, 10 kinds of VOCs released from the saliva were reported to be potential indicators for gastric cancer prewarning. To track these potential indicators with high specificity, a surface-enhanced Raman scattering (SERS) sensor based on a thin layer of MIL-100 (Fe) shell-wrapped Au nanostars (Au-star) was developed, and part of the aforementioned VOC indicators (e.g., 2-butanone, eucalyptol, and isopropanol) were found to be selectively detected by the sensor. These pilot results indicate a bright future for the proposed strategy for disease screening and the design of future high-performance SERS sensors.
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