小脑
焦虑
谷氨酸的
扁桃形结构
抗焦虑药
神经科学
心理学
抑制性突触后电位
谷氨酸受体
医学
精神科
内科学
受体
作者
Xiaoyang Zhang,Weiwei Wu,Li-Ping Shen,Miao‐Jin Ji,Pengfei Zhao,Lei Yu,Jun Yin,Shutao Xie,Yun-Yong Xie,Yang-Xun Zhang,Hongzhao Li,Qipeng Zhang,Chen‐Hua Yan,Fei Wang,Chris I. De Zeeuw,Jianjun Wang,Jing-Ning Zhu
出处
期刊:Neuron
[Elsevier]
日期:2024-01-01
被引量:2
标识
DOI:10.1016/j.neuron.2024.01.007
摘要
Physical exercise is known to reduce anxiety, but the underlying brain mechanisms remain unclear. Here, we explore a hypothalamo-cerebello-amygdalar circuit that may mediate motor-dependent alleviation of anxiety. This three-neuron loop, in which the cerebellar dentate nucleus takes center stage, bridges the motor system with the emotional system. Subjecting animals to a constant rotarod engages glutamatergic cerebellar dentate neurons that drive PKCδ+ amygdalar neurons to elicit an anxiolytic effect. Moreover, challenging animals on an accelerated rather than a constant rotarod engages hypothalamic neurons that provide a superimposed anxiolytic effect via an orexinergic projection to the dentate neurons that activate the amygdala. Our findings reveal a cerebello-limbic pathway that may contribute to motor-triggered alleviation of anxiety and that may be optimally exploited during challenging physical exercise.
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