氧化三甲胺
肠道菌群
失调
化学
柠檬醛
精油
生物
生物化学
微生物学
食品科学
三甲胺
作者
Suraphan Panyod,Wei‐Kai Wu,Sin-Yi Peng,Yea-Jing Tseng,Ya-Chi Hsieh,Rou-An Chen,Huai-Syuan Huang,Yi‐Hsun Chen,Hsiao-Li Chuang,Cheng-Chih Hsu,Ting-Chin David Shen,Chih‐Fan Yeh,Chi‐Tang Ho,Ming‐Shiang Wu,Lee‐Yan Sheen
标识
DOI:10.1038/s41538-023-00196-0
摘要
Recently, the role of the gut microbiota in diseases, including cardiovascular disease (CVD), has gained considerable research attention. Trimethylamine-N-oxide (TMAO), which is formed during ʟ-carnitine metabolism, promotes the formation of atherosclerotic plaques, causing thrombosis. Here, we elucidated the anti-atherosclerotic effect and mechanism of ginger (Zingiber officinale Roscoe) essential oil (GEO) and its bioactive compound citral in Gubra Amylin NASH (GAN) diet with ʟ-carnitine-induced atherosclerosis female ApoE-/- mice. Treatment with GEO at both low and high doses and citral inhibited the formation of aortic atherosclerotic lesions, improved plasma lipid profile, reduced blood sugar, improved insulin resistance, decreased plasma TMAO levels, and inhibited plasma inflammatory cytokines, especially interleukin-1β. Additionally, GEO and citral treatment modulated gut microbiota diversity and composition by increasing the abundance of beneficial microbes and decreasing the abundance of CVD-related microbes. Overall, these results showed that GEO and citral may serve as potential dietary supplements for CVD prevention by improving gut microbiota dysbiosis.
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