2019年冠状病毒病(COVID-19)
化学
高效液相色谱法
双层
色谱法
生物化学
医学
膜
疾病
病理
传染病(医学专业)
作者
Xintong Yu,Chuanfei Yu,Xiaohong Wu,Yu Chen,Xiaoda Liu,Yan Jin,Yuhua Li,Lan Wang
出处
期刊:Vaccines
[MDPI AG]
日期:2023-05-04
卷期号:11 (5): 937-937
被引量:6
标识
DOI:10.3390/vaccines11050937
摘要
Lipid nanoparticles (LNPs) are widely used as delivery systems for mRNA vaccines. The stability and bilayer fluidity of LNPs are determined by the properties and contents of the various lipids used in the formulation system, and the delivery efficiency of LNPs largely depends on the lipid composition. For the quality control of such vaccines, here we developed and validated an HPLC-CAD method to identify and determine the contents of four lipids in an LNP-encapsulated COVID-19 mRNA vaccine to support lipid analysis for the development of new drugs and vaccines.
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