癌细胞
癌症
转移
化学
芹菜素
作用机理
自噬
免疫系统
癌症研究
细胞凋亡
血管生成
药理学
生物
生物化学
类黄酮
免疫学
体外
抗氧化剂
遗传学
作者
Yun Zhou,Yijun Yu,Liang‐Nian He,Hao Zhang,Tianzi Liang,Guoer Zhou,Liping Huang,Yizhou Tian,Wenqing Liang
标识
DOI:10.1016/j.fct.2022.113385
摘要
Apigenin (APG) is a flavonoid presence in beverages, vegetables, and fruits containing anti-diabetic, anti-oxidant, and anti-viral activities, as well as cancer management properties. There is growing evidence that APG presented extensive anti-cancer effects in several cancer types by modulating various cellular processes, including angiogenesis, apoptosis, metastasis, autophagy, cell cycle, and immune responses, through activation or inhibition of different cell signaling pathways and molecules. By emerging nanotechnology and its advent in the biomedicine field, cancer therapy has been changed based on nanotechnology-based delivery systems. APG nanoformulations have been used to target tumor cells specifically, improve cellular uptake of APG, and overcome limitations of the free form of APG, such as low solubility and poor bioavailability. In this review, the biotherapeutic activity of APG and its mechanisms, both in free form and nanoformulation, toward cancer cells are discussed to shed some light on APG anti-tumor activity in different cancers.
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