材料科学
葡萄糖氧化酶
声动力疗法
活性氧
肖特基势垒
肿瘤微环境
化学
纳米技术
生物物理学
癌症研究
生物化学
光电子学
生物传感器
医学
生物
二极管
肿瘤细胞
作者
Yinmin Zhao,Jiahui Liu,Mengting He,Qi Dong,Lei Zhang,Zhigang Xu,Yuejun Kang,Peng Xue
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-07-29
卷期号:16 (8): 12118-12133
被引量:33
标识
DOI:10.1021/acsnano.2c02540
摘要
To date, the construction of heterogeneous interfaces between sonosensitizers and other semiconductors or noble metals has aroused increasing attention, owing to an enhanced interface charge transfer, augmented spin-flip, and attenuated activation energy of oxygen. Here, a smart therapeutic nanoplatform is constructed by surface immobilization of glucose oxidase (GOx) onto a TiO2@Pt Schottky junction. The sonodynamic therapy (SDT) and starvation therapy (ST) mediated by TiO2@Pt/GOx (TPG) promote systemic tumor suppression upon hypoxia alleviation in tumor microenvironment. The band gap of TiO2@Pt is outstandingly decreased to 2.9 eV, in contrast to that of pristine TiO2. The energy structure optimization enables a more rapid generation of singlet oxygen (1O2) and hydroxyl radicals (•OH) by TiO2@Pt under ultrasound irradiation, resulting from an enhanced separation of hole-electron pair for redox utilization. The tumorous reactive oxygen species (ROS) accumulation and GOx-mediated glucose depletion facilitate oxidative damage and energy exhaustion of cancer cells, both of which can be tremendously amplified by Pt-catalyzed oxygen self-supply. Importantly, the combinatorial therapy triggers intense immunogenetic cell death, which favors a follow-up suppression of distant tumor and metastasis by evoking antitumor immunity. Collectively, this proof-of-concept paradigm provides an insightful strategy for highly efficient SDT/ST, which possesses good clinical potential for tackling cancer.
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