医学
发病机制
内型
骨膜炎
生物信息学
疾病
计算生物学
免疫学
病理
生物
遗传学
细胞外基质
作者
Junqin Bai,Bruce K. Tan,Atsushi Kato
出处
期刊:Current Opinion in Allergy and Clinical Immunology
[Ovid Technologies (Wolters Kluwer)]
日期:2023-11-15
卷期号:24 (1): 1-8
标识
DOI:10.1097/aci.0000000000000954
摘要
This review aims to provide updates in realms of endotypic heterogeneity, pathogenesis at the molecular level, potential of biomarkers, and cutting-edge scope of biologics in CRS.High-dimensional analyses, such as transcriptomes, and machine learning, have significantly enhanced CRS endotyping, uncovering diverse pathogenetic mechanisms contributing to its heterogeneity. The dynamic process of epithelial remodeling in CRS pathogenesis has gained more clarity and support as exemplified by IL-13 and oncostatin M (OSM) that are shown intricately linked to epithelial barrier dysfunction. Moreover, anti-dsDNA autoantibody, BAFF, periostin, and cystatin SN show promise as potentials biomarkers, offering diagnostic and prognostic value for CRS.The identification of inflammatory molecules involved in endotype specific signaling pathways provides insights into the underlying mechanisms and verifiable biomarkers for diagnosis and prediction of disease severity. More comprehensive clinical studies should be conducted to facilitate biologics from bench to bedside in treating CRS.
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