入射(几何)
医学
炎症性肠病
溃疡性结肠炎
人口
队列
人口学
疾病
队列研究
克罗恩病
儿科
内科学
环境卫生
光学
物理
社会学
作者
K R Nielsen,J Midjord,Søren Nymand Lophaven,Ebbe Langholz,T. Hammer,Johan Burisch
出处
期刊:Journal of Crohn's and Colitis
[Oxford University Press]
日期:2023-09-05
标识
DOI:10.1093/ecco-jcc/jjad155
摘要
Abstract Background and Aims The highest reported incidence rate of inflammatory bowel disease [IBD], and especially of ulcerative colitis [UC], is found in the Faroe Islands. This study aimed to assess the incidence rate and temporal trends in prevalence over six decades. Methods All incident and prevalent patients diagnosed with IBD between 1960 and 2020 from the nationwide and population-based Faroese IBD cohort were included in this study. All patients fulfilled the Copenhagen Diagnostic Criteria. Results Overall, 873 individuals were diagnosed with IBD during the study period, 559 [64%] with UC, 151 [17%] with Crohn’s disease, and 163 [19%] with IBD unclassified. A total of 59 patients had paediatric-onset IBD. The incidence of IBD continued to increase throughout the study period, as the age-standardized incidence rate started at 8 per 100 000 person-years [py] [European Standard Population, ESP] in 1960–79 and reached 70 by 2010–20. In 2021, the age-standardized period prevalence was 1414 per 100 000 persons. The IBD incidence was unevenly distributed among the islands with Sandoy having the highest rate of 106 per 100 000 py in 2010–2020. Conclusions The incidence of IBD continues to increase in the Faroe Islands, mainly driven by UC. The incidence shows an uneven geographical distribution, which suggests an adverse interaction between unknown environmental factors and genetic traits. The prevalence in 2021 corresponded to 1.3% of the Faroese population. Environmental risk factors are suspected to impact this homogeneous high-risk population; however, the reason for this is unclear.
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