A high seizure burden increases brain concentrations of specialized pro-resolving mediators in Scn1a mouse model of Dravet syndrome

Dravet syndrome is a severe, intractable epilepsy in which 80% of patients have a de novo mutation in the gene SCN1A. We recently reported that a high seizure burden increased hippocampal concentrations of an array of pro-inflammatory prostaglandins in the Scn1a