摘要
Small MethodsVolume 7, Issue 7 2201706 Research Article Assembling AgAuSe Quantum Dots with Peptidoglycan and Neutrophils to Realize Enhanced Tumor Targeting, NIR (II) Imaging, and Sonodynamic Therapy Ling Yang, Ling Yang State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026 ChinaSearch for more papers by this authorMeng Yuan, Meng Yuan State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026 ChinaSearch for more papers by this authorPing'an Ma, Ping'an Ma State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026 ChinaSearch for more papers by this authorXiaorui Chen, Corresponding Author Xiaorui Chen [email protected] State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorZiyong Cheng, Corresponding Author Ziyong Cheng [email protected] orcid.org/0000-0002-9434-1046 State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026 China Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, 523808 Dongguan, China E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorJun Lin, Corresponding Author Jun Lin [email protected] orcid.org/0000-0001-9572-2134 State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026 China E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this author Ling Yang, Ling Yang State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026 ChinaSearch for more papers by this authorMeng Yuan, Meng Yuan State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026 ChinaSearch for more papers by this authorPing'an Ma, Ping'an Ma State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026 ChinaSearch for more papers by this authorXiaorui Chen, Corresponding Author Xiaorui Chen [email protected] State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorZiyong Cheng, Corresponding Author Ziyong Cheng [email protected] orcid.org/0000-0002-9434-1046 State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026 China Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, 523808 Dongguan, China E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorJun Lin, Corresponding Author Jun Lin [email protected] orcid.org/0000-0001-9572-2134 State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026 China E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this author First published: 24 April 2023 https://doi.org/10.1002/smtd.202201706Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Significant progress is made in drug delivery systems, but they still face problems such as poor stability in vivo, off-target drugs, and difficulty in crossing biological barriers. It is urgent to realize efficient targeted delivery and precisely controlled sustained release of drugs by using the integrated nanoplatform. Theranostic nanoplatform is a new biomedical technology that combines diagnosis or monitoring of diseases with treatment. Here, an integrated strategy of diagnosis and treatment is reported for delivering NIR-II imaged and therapeutic AgAuSe quantum dots (QDs) carried by peptidoglycan multilayer networks of bacteria to hitchhike circulating neutrophils for targeting the tumor. The assembled nanomaterials have good stability, which can not only initiate endogenous cells for drug delivery and achieve efficient targeting, but also guide drug imaging with excellent fluorescence property. Meanwhile, the elimination of established solid tumor is achieved with the administration of sonodynamic therapy without recurrence. This drug system expands the application of endogenous cell to participate in drug delivery system. Thus, the assembly strategy demonstrates the potential of endogenous neutrophils in functioning as natural drug vehicles and the application of NIR-II fluorescent QDs in biomedical engineering. Conflict of Interest The authors declare no conflict of interest. Open Research Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. 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