Expression of the Transcription Factor FOXP3 in Human Peripheral Blood B-Cell Subtypes (CD19+CD39+ and CD19+CD39-) and Evaluation of Their Regulatory Function

FOXP3 is expressed on both CD19⁺CD39^- and CD19⁺CD39⁺ B lymphocytes. CD19⁺CD39^- cells showed high levels of IL-10 and low levels of FOXP3 mRNA. CD19⁺CD39^- B cells decreased the Th1 cells and were associated with β-cell function.