Rhodium(I)‐Catalyzed Asymmetric Cascade Reactions

Rhodium(I)-catalyzed asymmetric cascade reactions have emerged as powerful tools in contemporary organic synthesis, enabling efficient construction of complex molecular architectures. These transformations proceed through organorhodium intermediates, which undergo additions to reactive π-bonds, subsequently triggering cascade reactions with neighboring functional groups to effectively forge multiple carbon-carbon bonds and stereogenic centers in a single step under mild conditions. This article reviews the pioneering developments and recent breakthroughs from 2002 to 2024, highlighting the attractive advantages of rhodium(I)-catalyzed asymmetric cascade reactions and their profound impacts on synthetic organic chemistry.