An Update: Enzymatic Synthesis for Industrial Applications

Abstract Supported by rapid technological advancements, biocatalytic applications have matured into sustainable, scalable, and cost‐competitive alternatives to established chemical catalysis. This review presents the most recent examples of enzyme‐based solutions for the manufacturing of molecules with extended carbon–carbon frameworks and multiple stereogenic centers at commercial scale, including peptide building blocks, (rare) sugars, synthetic (oligo)nucleotides, and terpenoids, such as (–)‐Ambrox ® . Novel enzyme classes are highlighted along with their potential applications—the synthesis of DNA/RNA, the depolymerization of synthetic plastics, or fully enzymatic protection/deprotection schemes—pointing toward the diversification and broader industrial utilization of biocatalysis‐based processes.