Effects of therapeutic interventions on pain due to plantar fasciitis: A systematic review and meta-analysis

Objective To determine the effects of different therapeutic interventions that have ever been evaluated in randomized controlled trials on pain due to plantar fasciitis. Methods We searched different electronic databases until September 2022. Mean differences (MDs) and 95% confidence intervals (CIs) were calculated. The Grading of Recommendations Assessment, Development and Evaluation was used to evaluate the overall certainty evidence. Results A total of 236 studies met the study criteria, including 15,401 patients. Botulinum toxin MD −2.14 (CI: −4.15, −0.14), micronized dehydrated human amnion/chorion membrane injection MD −3.31 (CI: −5.54, −1.08), dry needling MD −2.34 (CI: −4.64, −0.04), low-dye taping MD −3.60 (CI: −4.16, −3.03), low-level laser therapy MD −2.09 (CI: −2.28, −1.90), myofascial releases MD −1.79 (CI: −2.63, −0.94), platelet-rich plasma MD −2.40 (CI: −4.16, −0.63), radiofrequency MD −2.47 (CI: −4.65, −0.29), and stretching MD −1.14 (CI: −2.02, −0.26) resulted in being effective treatments for pain when compared to the control in the short term. In the medium and long term, only extracorporeal shock wave therapy MD −0.97 (CI: −1.13, −0.81)/MD −2.49 (CI: −3.17, −1.82) was effective for improving pain when compared to the control. Conclusions Considering the available studies, this systematic review and meta-analysis showed that different therapeutic interventions seem to be useful strategies for improving pain in patients with plantar fasciitis. In the medium and long term, only extracorporeal shock wave therapy was effective in improving pain when compared to the control.