Hox基因
遗传学
基因
生物
计算生物学
进化生物学
基因表达
作者
Derek Lemons,William McGinnis
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2006-09-29
卷期号:313 (5795): 1918-1922
被引量:354
标识
DOI:10.1126/science.1132040
摘要
The family of Hox genes, which number 4 to 48 per genome depending on the animal, control morphologies on the main body axis of nearly all metazoans. The conventional wisdom is that Hox genes are arranged in chromosomal clusters in colinear order with their expression patterns on the body axis. However, recent evidence has shown that Hox gene clusters are fragmented, reduced, or expanded in many animals—findings that correlate with interesting morphological changes in evolution. Hox gene clusters also contain many noncoding RNAs, such as intergenic regulatory transcripts and evolutionarily conserved microRNAs, some of whose developmental functions have recently been explored.
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