颌骨骨坏死
医学
拔牙
荟萃分析
牙科
双膦酸盐相关性颌骨骨坏死
梅德林
相伴的
入射(几何)
系统回顾
相对风险
骨质疏松症
内科学
置信区间
双膦酸盐
政治学
法学
物理
光学
作者
Elise Gaudin,Laurence Seidel,Miljana Baćević,Eric Rompen,France Lambert
摘要
Abstract Aims The primary objective was to assess the occurrence rate of Medication‐Related OsteoNecrosis of the Jaw ( MRONJ ) after dental extraction in patients treated with Antiresorptive Drugs ( ARD ) for OsteoPorosis ( OP ) or for oncological reasons. The secondary objective was to compare the extraction techniques regarding the occurrence of MRONJ . Materials and Methods A systematic search in PubMed/ MEDLINE , EMBASE and LILACS databases was performed. Prospective studies considering human patients treated with ARD and providing information regarding the occurrence of MRONJ after dental extraction were selected. Meta‐analysis for incidence of MRONJ at the patient level was performed. The effect of administration route and surgical technique on MRONJ was evaluated. Results The risk of MRONJ after dental extraction was significantly higher in patients treated with ARD for oncological reasons (3.2%) than in those treated with per os ARD for OP (0.15%) ( p < 0.0001). Dental extraction performed with adjusted extraction protocols decreased significantly MRONJ development. Potential risk indicators such as concomitant medications and pre‐existing osteomyelitis were identified. Conclusion The risk of MRONJ after dental extraction in patients treated with ARD exists, especially in patients treated for oncologic reasons. This risk tends to decrease with adjusted extraction protocols.
科研通智能强力驱动
Strongly Powered by AbleSci AI