医学
乙酰辅酶A羧化酶
癌症
癌症研究
脂肪酸合成
限制
酶
细胞凋亡
生物化学
生物信息学
丙酮酸羧化酶
内科学
生物
机械工程
工程类
作者
Chao Wang,Jun Ma,Nan Zhang,Qin Yang,Yue Jin,Yu Wang
标识
DOI:10.1586/14737140.2015.1038246
摘要
As a rate-limiting enzyme, the acetyl-CoA carboxylase (ACC) is essential for fatty acid synthesis. Traditionally, the ACC has been a target of metabolic syndrome and obesity. Recent research has demonstrated that malignant tumors have a high energy flow, thus having a great ability to synthesize fatty acids. ACCs are occasionally found to be overexpressed in cancer cells, and using chemical or RNA interference to inhibit ACC can lead to cancer cell cycle arrest and apoptosis. This suggests that ACC and relative fatty acids may be critical for the survival of cancer cells. In this review, we summarize the role of ACC in tumor development. We also discuss the signaling pathways possibly affected by ACC, which may give insight into future research for cancer therapy.
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