榄香烯
癌症研究
肺癌
癌变
癌症
上皮-间质转换
巨噬细胞
辐射敏感性
医学
化学
免疫学
细胞凋亡
癌细胞
放射治疗
病理
内科学
转移
体外
生物化学
作者
Xiaomu Yu,Mingxi Xu,Na Li,Zongjuan Li,Hongye Li,Shujuan Shao,Kun Zou,Lijuan Zou
标识
DOI:10.1016/j.bbrc.2017.06.071
摘要
Macrophages in tumor are mostly M2-polarized and have been reported to promote tumorigenesis, which are also defined as tumor-associated macrophages (TAMs). β-elemene has therapeutic effects against several cancers, however, it remains unknown whether β-elemene could inhibit cancer by targeting TAMs. Herein, we examined the effect of β-elemene on macrophages to elucidate a novel mechanism of β-elemene in tumor therapy. We showed that the conditioned medium of M2 macrophages promoted lung cancer cells to migration, invasion and epithelial mesenchymal transition, which could be inhibited by β-elemene. Moreover, β-elemene regulated the polarization of macrophages from M2 to M1. β-elemene also inhibited the proliferation, migration, invasion of lung cancer cells and enhanced its radiosensitivity. These results indicate β-elemene suppresses lung cancer by regulating both macrophages and lung cancer cells, it is a promising drug for combination with chemotherapy or radiotherapy.
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