Microstructural Differences in the Corpus Callosum in Patients With Bipolar Disorder and Major Depressive Disorder

双相情感障碍 部分各向异性 胼胝体 重性抑郁障碍 磁共振弥散成像 狂躁 心理学 白质 情感障碍症 边缘型人格障碍 精神科 内科学 磁共振成像 心脏病学 医学 心情 神经科学 放射科
作者
Kiwamu Matsuoka,Fumihiko Yasuno,Toshifumi Kishimoto,Akira Yamamoto,Kuniaki Kiuchi,Jun Kosaka,Kazuyuki Nagatsuka,Hidehiro Iida,Takashi Kudo
出处
期刊:The Journal of Clinical Psychiatry [Physicians Postgraduate Press, Inc.]
卷期号:78 (01): 99-104 被引量:25
标识
DOI:10.4088/jcp.15m09851
摘要

Article AbstractObjective: It is difficult to distinguish between bipolar disorder and major depressive disorder (MDD) in patients lacking a clear history of mania. There is an urgent need for an objective biomarker for differential diagnosis. Using diffusion tensor imaging, this study investigated the differences in the brain white matter microstructure between patients with bipolar disorder and MDD.Methods: Participants included 16 patients with bipolar disorder and 23 patients with MDD having depressed or euthymic states based on DSM-IV-TR criteria and 23 healthy volunteers. Whole-brain voxel-based morphometric analysis was used to detect any significant differences in fractional anisotropy between patients with bipolar disorder and MDD. The study was conducted between August 2011 and July 2015.Results: We found a significant decrease in fractional anisotropy values in the anterior part of the corpus callosum in patients with bipolar disorder compared with MDD (P < .001), which did not depend on the patients†affective state. This decrease was associated with increased radial diffusivity values (P < .05), which was also found in patients with bipolar disorder when compared with healthy volunteers (P < .05). We predicted bipolar disorder and MDD in all patients using the fractional anisotropy values, with a correct classification rate of 76.9%.Conclusions: The present study revealed that patients with bipolar disorder have microstructural abnormalities in the corpus callosum during depressed or euthymic states, which may deteriorate the exchange of emotional information between the cerebral hemispheres, resulting in emotional dysregulation. Our results indicate the possible use of diffusion tensor imaging as a differential diagnostic tool.
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