痛风
医学
尿酸
药品
高尿酸血症
重吸收
内科学
药理学
肾
作者
Chaker Ben Salem,Raoudha Slim,Neila Fathallah,Houssem Hmouda
出处
期刊:Rheumatology
[Oxford University Press]
日期:2016-08-07
卷期号:: kew293-kew293
被引量:83
标识
DOI:10.1093/rheumatology/kew293
摘要
Hyperuricaemia is a common clinical condition that can be defined as a serum uric acid level >6.8 mg/dl (404 µmol/l). Gout, a recognized complication of hyperuricaemia, is the most common inflammatory arthritis in adults. Drug-induced hyperuricaemia and gout present an emergent and increasingly prevalent problem in clinical practice. Diuretics are one of the most important causes of secondary hyperuricaemia. Drugs raise serum uric acid level by an increase of uric acid reabsorption and/or decrease in uric acid secretion. Several drugs may also increase uric acid production. In this review, drugs leading to hyperuricaemia are summarized with regard to their mechanism of action and clinical significance. Increased awareness of drugs that can induce hyperuricaemia and gout, and monitoring and prevention are key elements for reducing the morbidity related to drug-induced hyperuricaemia and gout.
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