Effect of meropenem on pharmacokinetics of sodium valproate at steady state in rabbits

OBJECTIVE To observe the effects of inject meropenem on serum concentrations at steady state and its pharmacokinetics of sodium valproate(SVPA) in New Zealand rabbits.METHODS After oral administration of SVPA or SVPA combined with meropenem,the plasma drug levels were measured by high-performance liquid chromatography(HPLC).The plasma concentration-time data were accessed by non-linear program(WINNONL IN) and the pharmacokinetic parameters were obtained.RESULTS There was significant decreasing of SVPA blood concentration at peak value time(0.5 h and 1.5 h) inⅡstage(P0.05).Theeliminate(t1/2β) of SVPA inⅡstage was lower than that of Ⅰstage(P0.05).The other pharmacokinetics parameters were not changed significantly between two stages.CONCLUSION There was significant decreasing of SVPA blood when oral meropenem in New Zealand rabbits.They can be taken simultaneously,but the concentration of SVPA theohylline in plasma should be monitored.