质谱成像
质谱法
计算机科学
表征(材料科学)
生物标志物
H&E染色
外科病理学
医学物理学
医学
病理
化学
纳米技术
染色
材料科学
色谱法
生物化学
作者
Juliana Pereira Lopes Gonçalves,Christine Bollwein,Wilko Weichert,Kristina Schwamborn
标识
DOI:10.1016/j.cll.2021.03.001
摘要
Mass spectrometry imaging (MSI) combines the excellence in molecular characterization of mass spectrometry with microscopic imaging capabilities of hematoxylin- and eosin-stained samples, enabling the precise location of several analytes in the tissue. Especially in the field of pathology, MSI may have an impactful role in tumor diagnosis, biomarker identification, prognostic prediction, and characterization of tumor margins during tumor resection procedures. This article discusses the recent developments in the field that are paving the way for this technology to become accepted as an analytical tool in the clinical setting, its current limitations, and future directions.
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