非酒精性脂肪肝
肝硬化
生物
肝细胞癌
脂肪肝
慢性肝病
疾病
非酒精性脂肪性肝炎
肝病
纤维化
肝星状细胞
内科学
胃肠病学
癌症研究
内分泌学
医学
生物化学
作者
Rohit Loomba,Scott L. Friedman,Gerald I. Shulman
出处
期刊:Cell
[Elsevier]
日期:2021-05-01
卷期号:184 (10): 2537-2564
被引量:821
标识
DOI:10.1016/j.cell.2021.04.015
摘要
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver injury that can lead to cirrhosis and hepatocellular carcinoma. Here we provide an in-depth discussion of the underlying pathogenetic mechanisms that lead to progressive liver injury, including the metabolic origins of NAFLD, the effect of NAFLD on hepatic glucose and lipid metabolism, bile acid toxicity, macrophage dysfunction, and hepatic stellate cell activation, and consider the role of genetic, epigenetic, and environmental factors that promote fibrosis progression and risk of hepatocellular carcinoma in NASH.
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