荧光
荧光寿命成像显微镜
材料科学
纳米颗粒
胶质母细胞瘤
近红外光谱
血液循环
生物物理学
生物医学工程
纳米技术
癌症研究
医学
光学
生物
物理
传统医学
作者
Shangyu Chen,Moonsik Han,Xinyue Jiang,Pengfei Sun,Quli Fan,Wei Huang
出处
期刊:Biomaterials
[Elsevier]
日期:2021-08-01
卷期号:275: 120916-120916
被引量:40
标识
DOI:10.1016/j.biomaterials.2021.120916
摘要
Fluorescence imaging (FI) in the second near-infrared region (NIR-II, 1000–1700 nm) has attracted great attention for brain tumor imaging due to its deep penetration and high resolution. However, traditional NIR-II organic fluorescent nanoparticles (NPs) are usually hindered by uncontrolled large size (~30–100 nm), marked aggregation-caused quenching (ACQ) effect, and limited blood circulation (~1–3 h), which have great impact on efficient NIR-II FI of deep brain tumors. Herein, starlike polymer brush-based ultrasmall TQFP-10 NPs, with bright NIR-II fluorescence, prolonged blood circulation, and enhanced tumor accumulation, are facilely prepared for efficient orthotopic glioblastoma (GBM) imaging. Compared with traditional method prepared NPs (physically coated [email protected] and PEG modified TQF-PEG5K NPs), the ultrasmall (~8 nm) TQFP-10 NPs display a higher NIR-II fluorescence QY (1.9%), which is 2.1- and 3.8-fold higher than [email protected] (0.9%) and TQF-PEG5K NPs (0.5%), respectively. In addition, TQFP-10 NPs present a 10.6-fold higher blood circulation half-life (t1/2 = 8.5 h) than that of TQF-PEG5K NPs. Consequently, TQFP-10 NPs exhibit 4.2- and 33-fold higher maximal tumor to normal tissue ratio in subcutaneous and in situ NIR-II FI of GBM, respectively, than [email protected] and TQF-PEG5K NPs, attractively realizing GBM imaging. This work provides a general strategy for constructing ultrasmall NIR-II fluorescent NPs with simultaneously improved NIR-II fluorescence and blood circulation for efficient brain tumor imaging.
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