材料科学
纳米技术
纳米医学
量子点
生物相容性
生物医学工程
荧光
纳米颗粒
光学
医学
物理
冶金
作者
Zhe Feng,Siyi Bai,Ji Qi,Chuan-bin Sun,Yuhuang Zhang,Xiaoming Yu,Huwei Ni,Di Wu,Xiaohui Fan,Dingwei Xue,Shunjie Liu,Ming Chen,Junyi Gong,Peifa Wei,Mubin He,Jacky W. Y. Lam,Xinjian Li,Ben Zhong Tang,Lixia Gao,Jun Qian
标识
DOI:10.1002/adma.202008123
摘要
Superb reliability and biocompatibility equip aggregation-induced emission (AIE) dots with tremendous potential for fluorescence bioimaging. However, there is still a chronic lack of design instructions of excretable and bright AIE emitters. Here, a kind of PEGylated AIE (OTPA-BBT) dots with strong absorption and extremely high second near-infrared region (NIR-II) PLQY of 13.6% is designed, and a long-aliphatic-chain design blueprint contributing to their excretion from an animal's body is proposed. Assisted by the OTPA-BBT dots with bright fluorescence beyond 1100 nm and even 1500 nm (NIR-IIb), large-depth cerebral vasculature (beyond 600 µm) as well as real-time blood flow are monitored through a thinned skull, and noninvasive NIR-IIb imaging with rich high-spatial-frequency information gives a precise presentation of gastrointestinal tract in marmosets. Importantly, after intravenous or oral administration, the definite excretion of OTPA-BBT dots from the body is demonstrated, which provides influential evidence of biosafety.
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