Di-tert-butylsilylene-Directed α-Selective Synthesis of 4-Methylumbelliferyl T-Antigen

We have succeeded in the facile synthesis of 4-methylumbelliferyl T-antigen as a substrate for endo-α-N-acetylgalactosaminidase by exploiting the combination of the di-tert-butylsilylene effect and the Mitsunobu reaction.