In vitro effects of the polyphenols resveratrol, mangiferin and (–)-epigallocatechin-3-gallate on the scuticociliate fish pathogen Philasterides dicentrarchi

DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsSpecials DAO 59:171-174 (2004) - doi:10.3354/dao059171 In vitro effects of the polyphenols resveratrol, mangiferin and (–)-epigallocatechin-3-gallate on the scuticociliate fish pathogen Philasterides dicentrarchi J. Leiro*, J. A. Arranz, A. Paramá, M. F. Álvarez, M. L. Sanmartín Laboratorio de Parasitología, Instituto de Investigación y Análisis Alimentarios, Universidad de Santiago de Compostela, Constantino Candeira 15782, Santiago de Compostela, Spain *Email: mpleiro@usc.es ABSTRACT: This study investigated the in vitro effects of the polyphenols resveratrol, mangiferin and (–)-epigallocatechin-3-gallate (EGCG) on the histiophagous ciliate Philasterides dicentrarchi, which causes fatal scuticociliatosis in farmed turbot Scophthalmus maximus L. Of the 3 polyphenols, resveratrol showed strongest antiprotozoal activity, reducing ciliate density after 1 wk culture by, on average, 91% at 50 µM, and 96% at 500 µM. EGCG reduced ciliate density by, on average, 93% at 500 µM, with no significant effect at 50 µM. Mangiferin reduced ciliate density by, on average, 56% at 500 µM, again with no significant effect at 50 µM. In view of these findings, we discuss the potential utility of chemotherapy with polyphenols as a strategy for the control of scuticociliatosis in farmed turbot. KEY WORDS: Polyphenols · Philasterides dicentrarchi · Resveratrol · Mangiferin · Epigallocatechin Full article in pdf format PreviousExport citation RSS - Facebook - Tweet - linkedIn Cited by Published in DAO Vol. 59, No. 2. Online publication date: May 05, 2004 Print ISSN: 0177-5103; Online ISSN: 1616-1580 Copyright © 2004 Inter-Research.