内科学
医学
单变量分析
白细胞
髓系白血病
CD19
肿瘤科
多元分析
川地34
胃肠病学
白血病
免疫学
生物
干细胞
遗传学
外周血
作者
Noriyoshi Iriyama,Yoshihiro Hatta,Tao Jin,Yoshiaki Ogawa,Shigeki Ohtake,Toru Sakura,Kinuko Mitani,Fumihiro Ishida,Masatomo Takahashi,Tomoya Maeda,Tohru Izumi,Hisashi Sakamaki,Shuichi Miyawaki,Sumihisa Honda,Yasushi Miyazaki,Tomohiko Taki,Masafumi Taniwaki,Tomoki Naoe
标识
DOI:10.1016/j.leukres.2013.05.002
摘要
We investigated the significance of surface antigen expression for prognosis by focusing on a specific subtype, AML with t(8;21). The investigation included 144 patients with AML with t(8;21) in the JALSG AML97 study. AML with t(8;21) expressed CD19 (36%), CD34 (96%), and CD56 (65%) more frequently than did other subtypes of AML. CD19 expression had a significant favorable effect on CR (95.7% vs. 83.8%; P = 0.049). Univariate analysis showed that increased white blood cell (WBC) counts (WBC ≥ 20 × 109/L), CD19 negativity, and CD56 positivity were critical adverse factors for relapse after CR; multivariate analysis revealed that WBC count and CD56 expression were independent adverse risk factors (HR 2.18; P = 0.045, HR 2.30; P = 0.011, respectively). We concluded that CD56 expression has a possible role in risk stratification for patients with AML with t(8;21).
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