免疫学
自身免疫
免疫系统
白细胞介素15
生物
受体
获得性免疫系统
细胞因子
异三聚体G蛋白
白细胞介素
遗传学
G蛋白
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2006-08-01
卷期号:6 (8): 595-601
被引量:984
摘要
Interleukin-2 and interleukin-15 have pivotal roles in the control of the life and death of lymphocytes. Although their heterotrimeric receptors have two receptor subunits in common, these two cytokines have contrasting roles in adaptive immune responses. The unique role of interleukin-2 is in the elimination of self-reactive T cells to prevent autoimmunity. By contrast, interleukin-15 is dedicated to the prolonged maintenance of memory T-cell responses to invading pathogens. As discussed in this Review, the biology of these cytokines will affect the development of novel therapies for malignancy and autoimmune diseases, as well as the design of vaccines against infectious diseases.
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