活性氧
氧气
化学
纳米颗粒
光化学
生物物理学
化学工程
微生物学
纳米技术
材料科学
生物
生物化学
有机化学
工程类
作者
Shiqi Peng,Rong Li,Yongfang Rao,Yu Huang,Yulei Zhao,Mingyu Xiong,Junji Cao,Shuncheng Lee
标识
DOI:10.1016/j.apcatb.2022.121693
摘要
In this study, reactive oxygen species (ROS)-mediated antibacterial activity with high efficiency in the dark was achieved by modulating the active sites of MIL-101(Fe) nanoparticles. The ROS production over x-MIL-101(Fe) nanoparticles was intensively enhanced by tuning the unsaturated iron sites (FeII/FeIII, the ratio was marked as x%). Electron paramagnetic resonance (EPR) analysis confirmedmore ROS generation on x-MIL-101(Fe) surface than that on MIL-101(Fe), due to more electrons shifting from benzene rings to FeII/FeIII sites. Among all samples, 8.9-MIL-101(Fe) displayed the highest inactivation efficiency (> 99.99%) against Escherichia coli within 2 h in the dark. ROS reacted with cell wall components to generate carbon-centered radicals via H abstraction, leading to the disruption of cell wall, intracellular ROS, and DNA damage. Antibacterial performance of 8.9-MIL-101(Fe) in air filters indicated 8.9-MIL-101(Fe) can be applied to prevent the spread of airborne pathogens. The results are promising for the ambient antibacterial application of MOF materials.
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