结直肠癌
医学
非甾体
癌症研究
癌症
内科学
作用机理
肿瘤科
作者
Denise L Cecil,Ekram A Gad,Lauren R Corulli,Nicholas Drovetto,Ronald A Lubet,Mary L Disis
出处
期刊:Cancer Prevention Research
[American Association for Cancer Research]
日期:2022-01-05
卷期号:: canprevres.0227.2021-canprevres.0227.2021
标识
DOI:10.1158/1940-6207.capr-21-0227
摘要
Nonsteroidal anti-inflammatories (NSAID) are an essential component of any combination chemoprevention of colon cancer. We show NSAID treatment reduces PD-L1 expression on intestinal tumor cells. NSAID regulation of PD-L1 is dependent on COX-2 expression. These data underscore an important immunologic mechanism of action for NSAID in colon cancer prevention.
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